Building the missing map of childhood gene expression
Deanne Taylor is creating a database to understand children's unique biology.
1Realizing the missing map
In 2017, Deanne Taylor was shocked to learn the Human Cell Atlas planned to study only adults. Knowing children's biology differs fundamentally, with gene expression variations dramatically altering drug responses, Taylor launched a research initiative focused on pediatric biology.
2White paper and mobilization
Taylor joined the Human Cell Atlas volunteer team, writing a dedicated children's section. Her 2019 paper aimed to attract funding to pediatric research, asking why we lack healthy models of child development. This became a landmark publication in the field.
3$38.5 million breakthrough
In 2021, NIH awarded $38.5 million to dGTEx to create the first comprehensive database of healthy pediatric tissue. The project maps gene expression across major organ systems using samples from deceased healthy children. Taylor's team standardizes each tissue donation's data.
4Database structure
dGTEx compiles family histories and sample details into a comprehensive dataset. An analysis team examines samples, combining all data to establish a reference for normal gene expression in children. This data will integrate with the Human Cell Atlas.
5Need for pediatric-specific treatments
Chemotherapy drugs can affect children's heart development, while some treatments trigger potentially fatal cytokine release syndrome. Taylor emphasizes understanding pediatric gene expression could reduce these risks and enable personalized treatments.
6Taylor's career journey
With a biophysics PhD, Taylor was inspired by the Human Genome Project to work on rare diseases at Pfizer. She later developed software detecting chromosomal abnormalities in embryos - many still in use today.
7Continuation of genome project
The Human Cell Atlas extends the 2003 Human Genome Project. While the genome map shows parts, the Cell Atlas explains how they're used throughout the body. Taylor notes this map remains incomplete without pediatric data.
8Interdisciplinary collaboration
Taylor bridges diverse research projects. The Human Cell Atlas's pediatric section exists thanks to her efforts. Sarah Teichmann highlights Taylor's holistic vision of pediatric development that transcends organ-specific studies.
Original article: MIT Technology Review — Çocuklarda gen ifadesi haritası oluşturma çalışmaları