# Former OpenAI exec Fidji Simo shares her battle with POTS and AI-powered cure plans Her startup ChronicleBio aims to revolutionize chronic disease treatment with 3,500 blood samples and AI analysis. - **Source:** [Fortune | FORTUNE](https://brifing.si/source/769282ef-327a-4454-909a-3c7936216004) - **Published:** 2026-08-03 - **Original article:** - **On Brifing:** https://brifing.si/s/6da93d91-4c4f-440c-b048-6b9363ec1962 ## What is POTS and why does it matter? Postural Orthostatic Tachycardia Syndrome (POTS) is a chronic condition causing dizziness, fatigue and brain fog upon standing due to autonomic nervous system dysfunction. Affecting millions worldwide, it significantly impacts daily life for patients like Fidji Simo. With no known cure, POTS represents a growing health challenge. Chronic diseases collectively cost the global economy hundreds of billions annually in lost productivity, highlighting the urgent need for innovative solutions in this underserved medical area. ## Fidji Simo's health journey After serving as OpenAI's CEO of AGI Deployment and holding executive roles at Meta and Instacart, Simo stepped down due to her seven-year battle with POTS. She founded ChronicleBio to make meaningful progress against chronic illnesses. Currently experiencing her 'physical worst,' Simo balances medical treatments with growing her startup while maintaining an advisory role at OpenAI. Her personal struggle fuels her mission to transform chronic disease treatment through technology. ## ChronicleBio's innovative approach Simo's startup leverages AI and big data to identify subtypes within chronic diseases. In its first year, ChronicleBio collected 890 blood samples from 709 patients across Utah, Arizona, Texas and India. Their biobank now holds over 3,500 blood tubes, generating 153 terabytes of data - triple the training data used for OpenAI's GPT-3.5 model. This massive dataset enables unprecedented biological insights into disease mechanisms, forming the foundation for targeted therapies. ## Mobile blood collection service On August 11, ChronicleBio will launch mobile phlebotomy trucks for at-home blood collection from chronic disease patients. The first 250 participants will receive free comprehensive health reports in exchange for contributing their biological data. This initiative aims to improve clinical trial success rates by capturing diverse patient data more efficiently. The convenience of home collection addresses participation barriers while building a more representative research database for precision medicine breakthroughs. ## Revolutionizing clinical trials Simo explains why current drug trials fail: 'Patients with the same diagnosis may have biologically distinct subtypes. A drug working for one subgroup might be ineffective for others.' ChronicleBio has already identified five biologically distinct subgroups within POTS patients. This understanding enables matching existing drugs to responsive subgroups, with testing planned before year-end. The approach could salvage potentially effective drugs previously abandoned due to blanket trial failures. ## The sub-disease concept Traditional medicine names syndromes like POTS by symptoms rather than biological causes. ChronicleBio's research reveals that patients with identical symptoms may have different underlying biological drivers - whether immune system dysfunction, mitochondrial issues or other mechanisms. By mapping these distinctions, the company enables development of targeted therapeutics for each biological subtype. This precision approach marks a paradigm shift from one-size-fits-all treatments to personalized medicine for chronic conditions. ## Data scale and AI's role ChronicleBio's 153-terabyte dataset exceeds conventional analysis capabilities. AI algorithms can detect patterns invisible to human researchers in this vast biological data. The company applies AI expertise from OpenAI to healthcare challenges. Large language models show particular promise for medical data analysis, potentially revolutionizing treatment protocols. This AI-powered approach could dramatically accelerate drug development while reducing costs through more efficient trial designs and higher success rates. ## Funding and growth plans ChronicleBio has raised $15 million to date, funding biobank expansion and AI platform development. The company plans partnerships with biotech and pharmaceutical firms. Simo's industry network provides significant growth advantages, while her ongoing connections with OpenAI leadership facilitate technology transfer. Future initiatives will focus on increasing patient participation and data diversity to strengthen the research foundation for precision chronic disease treatments. ## Personalized medicine for chronic conditions ChronicleBio represents personalized medicine's application to chronic diseases, moving beyond the 'one drug fits all' model. By matching treatments to patients' biological profiles, the approach shows particular promise for heterogeneous conditions like long COVID. The model could increase clinical trial success rates while reducing drug development costs. If successful, the methodology might extend to other complex conditions like diabetes, potentially transforming treatment paradigms across multiple disease categories. ## Ethics and data privacy ChronicleBio's model raises important questions about ethical data use. The company offers free health reports in exchange for participants' biological data, emphasizing voluntary participation. However, regulations governing big data and AI in medicine continue evolving. ChronicleBio's data security and patient privacy policies will prove crucial for maintaining trust as the company scales. Balancing research needs with individual rights remains an ongoing challenge in precision medicine initiatives. ## The future of chronic disease treatment Fidji Simo's story offers hope for millions living with chronic illnesses. ChronicleBio's AI-powered approach holds groundbreaking potential for medicine. Success could herald a new era in chronic disease management, though technological, ethical and regulatory hurdles remain. Shaped by Simo's personal struggle, this venture may redefine healthcare's future by demonstrating how technology can address some of medicine's most persistent challenges through data-driven, patient-centered innovation. ## Sources covering this story - https://fortune.com/2026/08/03/fidji-simo-discusses-pots-diseases-chroniclebio-ai-startup-openai/ — --- _Summary written by Brifing from the original reporting. Copyright in the original article belongs to its publisher; read the full piece at the link above._