# European Colonizers Brought Smallpox to Americas, Mummy DNA Confirms 500-year-old mummies carry traces of the colonial-era pandemic that devastated indigenous populations. - **Source:** [Gizmodo](https://brifing.si/source/63382431-cef0-4c41-883e-2f88dc21351e) - **Published:** 2026-08-03 - **Original article:** - **On Brifing:** https://brifing.si/s/9abca5b0-e9ab-422a-9657-7473b27efdc0 ## Genetic Proof of Historical Claim Scientists analyzed DNA from two Inca mummies found in northern Chile in 1990. The individuals, who died between the 15th and 17th centuries, hosted a lost strain of smallpox virus known to have affected Europeans during the same period. This discovery provides the first molecular evidence that colonizers introduced smallpox to the Americas. Skin lesions previously attributed to arsenic exposure were reidentified as smallpox symptoms through advanced genomic analysis. ## Victims of the Same Outbreak Nearly identical viral traces in both mummies suggest they died during the same smallpox outbreak. The remains of a woman in her 30s and a man in his 20s were discovered at an indigenous burial site. Researchers initially aimed to study regional population history but unexpectedly uncovered smallpox DNA. These findings reveal the devastating impact of colonial-era epidemics on native populations. ## The Virus's Evolutionary Journey This viral strain bridges an evolutionary gap between medieval European variants and those circulating in the 19th century. Data shows the virus evolved slower during peak colonial expansion. Geneticist Lara Cassidy explains this was due to indigenous populations' lack of immunity: "The virus could spread successfully with little adaptation." This biological vulnerability had catastrophic demographic consequences. ## Vaccination as Turning Point The virus resumed rapid evolution after English physician Edward Jenner developed the smallpox vaccine in the 19th century. As vaccination rates increased, so did protection against the disease. The World Health Organization declared smallpox eradicated in 1980. This study exemplifies how medical advancements like vaccination have shaped human history and altered disease trajectories. ## Scientific Community Reacts Ana Duggan of Canada's Public Health Agency noted that while two genomes may seem limited, they represent a major leap in understanding historical variola viruses. Indiana University's Patricia Foster stated: "No one doubted colonization brought smallpox, but this proves it." Lead author Bruno Romero González emphasized ancient DNA's power to resolve longstanding historical questions. ## Microbiological Legacy of Colonialism The research demonstrates how major historical events like colonization shaped infectious disease evolution. Indigenous populations' immunological naivety led to millions of deaths. Scientists note such studies help understand past pandemic dynamics and extract lessons for future preparedness. The intersection of history and microbiology reveals colonialism's biological dimensions. ## Potential of Ancient DNA This discovery reaffirms ancient DNA's role in solving historical mysteries. Researchers plan to trace other historical epidemics using similar techniques. Investigating genetic origins of diseases introduced during colonization could illuminate complex relationships between human migration and pathogen spread. Each sample adds pieces to humanity's epidemiological puzzle. ## Where History Meets Science Mummy-derived insights illuminate not just medical history but human civilization. Smallpox's demographic collapse permanently altered the Americas' social fabric. This study reminds us of science's power—and ethical responsibility—to illuminate dark chapters. Scientific evidence plays an increasing role in historical justice, offering tangible connections to intangible pasts. ## Sources covering this story - https://gizmodo.com/chilean-mummies-prove-europeans-brought-smallpox-to-the-americas-but-thats-not-all-2000794066 — --- _Summary written by Brifing from the original reporting. Copyright in the original article belongs to its publisher; read the full piece at the link above._