# Clinical Case: Vertigo and Multifocal Brain Lesions A 35-year-old woman presents with recurrent vertigo and mysterious neurological findings. - **Source:** [The Lancet – Online First](https://www.thelancet.com) - **Published:** 2026-11-06 - **Topic:** [health](https://brifing.si/c/health) - **Original article:** - **On Brifing:** https://brifing.si/s/c9ad812a-6da4-42eb-9581-7915da7761c1 ## Patient Clinical Presentation A 35-year-old woman sought medical evaluation for a one-year history of recurrent vertigo. These episodes lasted approximately fifteen minutes and were described as a spinning sensation. Notably, the patient reported no associated symptoms such as headaches, tinnitus, hearing loss, or visual disturbances during these brief, non-positional episodes of dizziness. ## Initial Diagnostic Findings Physical examinations revealed stable vital signs, with normal blood pressure readings. The patient exhibited no signs of orthostatic hypotension or tachycardia upon standing, which often rules out common cardiovascular causes of dizziness. Neurological and vestibular assessments, including the Dix-Hallpike manoeuvre, were entirely normal when the patient was between the symptomatic episodes. ## Vestibular Function Assessment Audiometry testing was performed to assess potential inner ear involvement, yielding normal results. The absence of auditory symptoms or abnormal vestibular exam findings suggests that the vertigo may not originate from peripheral vestibular structures. This necessitates a broader investigation into central nervous system pathways that could explain the recurrent spinning sensations. ## Differential Diagnosis Challenges The clinical challenge lies in the discrepancy between the patient's reported vertigo and the lack of objective findings during examinations. Because the vertigo is non-positional, clinicians must consider central causes rather than benign paroxysmal positional vertigo. The presence of multifocal brain lesions, as noted in the case title, remains the primary diagnostic focus. ## Role of Skin Clues The case highlights a diagnostic clue on the skin, which often serves as a critical indicator in systemic or neurological conditions. Dermatological manifestations can provide essential evidence for underlying inflammatory or autoimmune processes. Clinicians must correlate these skin findings with the multifocal brain lesions to determine the specific underlying pathology involved. ## Neurological Lesion Implications Multifocal brain lesions indicate that the pathology is not localized to a single area, suggesting a disseminated process. Such lesions could be related to demyelinating diseases, infectious etiologies, or vasculitis. Understanding the distribution of these lesions is vital for narrowing the differential diagnosis and planning appropriate imaging studies like magnetic resonance imaging. ## Diagnostic Pathway Strategy The diagnostic strategy involves integrating the patient's history of vertigo with findings from neurological imaging and dermatological inspection. By connecting the skin findings to the brain lesions, physicians can identify a unifying diagnosis. This systematic approach is necessary to distinguish between various neurological disorders that present with non-specific, recurrent vestibular symptoms. ## Clinical Significance Summary This case underscores the importance of a comprehensive physical examination beyond the primary complaint. Even when standard vestibular tests are normal, persistent vertigo warrants deeper investigation into systemic conditions. Identifying the link between skin abnormalities and central nervous system lesions is essential for accurate diagnosis and effective long-term management of the patient. ## Sources covering this story - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00695-1/fulltext?rss=yes — --- _Summary written by Brifing from the original reporting. Copyright in the original article belongs to its publisher; read the full piece at the link above._