# New Drug Baxdrostat Could Permanently Cure High Blood Pressure A breakthrough medication may replace surgery for patients with adrenal gland-related hypertension. - **Source:** [iNews](https://inews.co.uk) - **Published:** 2026-11-07 - **Topic:** [health](https://brifing.si/c/health) - **Original article:** - **On Brifing:** https://brifing.si/s/d6cc4410-a16a-4e11-b5f1-edbf8acd27b1 ## Breakthrough in Hypertension Treatment A new medication called baxdrostat has demonstrated potential as a permanent cure for specific cases of high blood pressure. Originally designed to inhibit the hormone aldosterone, the drug unexpectedly kills cells in adrenal gland tumours. This discovery offers a non-surgical alternative for patients whose hypertension is driven by these tiny benign growths. ## Mechanism of Cellular Destruction Baxdrostat functions by blocking aldosterone production, which triggers the generation of harmful reactive oxygen species within the cells. These compounds effectively destroy the hormone-producing tumour cells located on the adrenal glands. This process mimics the therapeutic benefits currently achieved only through major surgical removal of the affected adrenal gland tissue. ## Clinical Trial Observations In a study involving 14 patients, participants who took the drug for six to 12 months maintained lower blood pressure levels after stopping treatment. One individual remained off the medication for three years with sustained results. These findings suggest that a finite course of daily pills could provide long-term remission for patients. ## Targeting Stubborn Blood Pressure The drug is primarily intended for patients whose blood pressure remains dangerously high despite using two or more standard medications. Research indicates that approximately one in ten people with hypertension may have adrenal gland tumours as the underlying cause. These individuals are the primary candidates for this potential new curative treatment approach. ## Regulatory Status and Availability Baxdrostat received approval in the United States this year for patients with resistant hypertension. In the United Kingdom, the National Institute for Health and Care Excellence is currently evaluating the drug for potential NHS provision. Officials anticipate the treatment could become available to British patients as early as the year 2027. ## Expert Perspectives on Efficacy Professor Morris Brown of Queen Mary University of London noted that the drug fulfills a long-held ambition to transition from chronic management to a permanent cure. While the initial results are promising, experts emphasize that larger studies are currently underway to confirm the durability of these findings across a broader patient population. ## Impact on Patient Care The potential shift from invasive adrenal surgery to a daily pill represents a significant advancement in cardiovascular medicine. By targeting the root cause of hormone overproduction, the treatment could benefit over a million people in the UK. This approach reduces the reliance on lifelong medication for a substantial subgroup of hypertensive patients. ## Future Research Directions Researchers are now focused on gathering longer-term data to substantiate the claim of an infinite cure through a finite medication course. The ongoing larger trial will provide the necessary evidence to validate these extraordinary findings. Future clinical outcomes will determine if this drug becomes a standard protocol for treating adrenal-related hypertension. ## Sources covering this story - https://inews.co.uk/news/high-blood-pressure-permanent-cure-4875408 — --- _Summary written by Brifing from the original reporting. Copyright in the original article belongs to its publisher; read the full piece at the link above._