# Testosterone Linked to Gender Differences in Temperature Sensitivity New research suggests testosterone influences skin sensors, explaining why females often prefer warmer environments. - **Source:** [Latest from Live Science](https://www.livescience.com/feeds.xml) - **Published:** 2026-11-07 - **Topic:** [science](https://brifing.si/c/science) - **Original article:** - **On Brifing:** https://brifing.si/s/f7977df2-d336-41df-8b0e-4f0c807c214b ## Biological Basis of Warmth A study published October 28 in the Journal of Physiology explores why females often prefer warmer temperatures than males. Researchers observed this trend in mice, noting that female mice consistently sought out warmer surfaces. This behavior mirrors common observations in humans, suggesting a shared biological mechanism across different mammalian species. ## Sensory Protein Activation Skin nerve endings contain proteins acting as electrical generators that detect heat and cold. The study found these sensors activate at higher temperatures in female mice compared to males. This shift causes females to prefer temperatures roughly 7 degrees Fahrenheit higher, driven by the specific activation thresholds of these sensory proteins. ## Experimental Mouse Methodology Researchers placed 30 male and 27 female mice on plates with varying temperatures to track their preferences. While both sexes preferred 91.4 degrees Fahrenheit when the alternative was cooler, females spent significantly more time on a 100.4 degree plate. Internal body temperatures remained identical, isolating skin sensors as the primary driver. ## The Role of Testosterone Testosterone appears to be a key determinant in temperature preference. When researchers blocked testosterone production in male mice, their preference shifted toward warmer surfaces, resembling female behavior. Conversely, administering testosterone to female mice reduced their preference for warmth. These hormonal changes occurred over weeks, suggesting an indirect influence on gene activity. ## Hormonal Specificity Findings The study tested various hormones to determine their impact on thermal perception. While testosterone significantly influenced temperature sensitivity, female hormones like estrogen and progesterone showed no effect on the mice's preferences. This indicates that testosterone specifically modulates the function of heat-sensing nerves, though it does not fully account for all differences. ## Mechanism and Limitations The exact mechanism by which testosterone impacts sensor proteins remains unclear. Because the observed effects developed over several weeks, researchers believe the hormone does not directly interact with the proteins. Instead, it likely influences gene expression indirectly. The study noted that testosterone did not completely reverse all sex-based thermal differences. ## Broader Medical Implications Understanding how sensory proteins function provides valuable insights into human physiology. Dr. Michael Caterina noted that these mechanisms are relevant to studying neuropathic pain, where sensitivity to heat and cold is often heightened. Mapping these signals helps scientists better understand how the human body processes daily environmental experiences and thermal sensations. ## Practical Design Applications Beyond basic biology, these findings have practical ramifications for architecture and interior design. Peter McNaughton suggests that understanding sex-based temperature preferences is essential for designing buildings and shared spaces that accommodate everyone comfortably. Recognizing these physiological differences could lead to more inclusive environmental controls in offices and public infrastructure projects. ## Sources covering this story - https://www.livescience.com/health/neuroscience/women-often-get-cold-more-easily-than-men-a-mouse-study-offers-hints-why — --- _Summary written by Brifing from the original reporting. Copyright in the original article belongs to its publisher; read the full piece at the link above._